Refractometers for the Pharmaceutical and Toxicology industries.

Refractometer users in pharmaceutical research, toxicology testing, compounding, and drug monitoring may require instruments with reliable temperature control, compliance tracking, and specific measurement ranges.  Does your application require you to measure …

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Enflurane, Sevoflurane and similar halogenated ethers are used extensively for the induction and maintenance of general anesthesia. Their manufacture must comply with specifications from the USP/EP or relevant pharmacopeias. Many of these pharmacopeias require the measurement of refractive index. For example, the US Pharmacopeia requires that sevoflurane has a refractive index of 1.2745 – 1.2760 at 20°C. For 21 CFR Part 11 compliance choose MMC option.

Refractometer Model	Specification	Features and Benefits
	Measurement Range: 1.26 – 1.70 RI; 0 – 95% Brix Accuracy:0.0001 RI; 0.1 Brix Electronic Temperature Control:Flexible temperature selection between 15°C – 70°C	USP General Subchapter <831> Refractive Index States: …Although the standard temperature for Pharmacopeial measurements is 25°C, many of the refractive index specifications in the individual monographs call for determining this value at 20°C. The temperature should be carefully adjusted and maintained, since the refractive index varies with the temperature… …To achieve the theoretical accuracy of ±0.0001, it is necessary to calibrate the instrument against a standard provided by the manufacturer and to check frequently the temperature control and cleanliness of the instrument by determining the refractive index of distilled water, which is 1.3330 at 20°C and 1.3325 at 25°C… The J357-MMC-CC refractometer provides the refractive index range, accuracy, performance and 21CFR Part 11 compliance demanded by large pharmaceutical firms making this our most popular pharmaceutical refractometer model.
	Measurement Range: 1.26 – 1.70 RI; 0 – 95% Brix Accuracy:0.00004 RI; 0.03 Brix Electronic Temperature Control:Flexible temperature selection between 15°C – 100°C; TB option: allows 15°C – 110°C with one hour boost to 120°C
Medical Testing and Toxicology Models	Specification	Features and Benefits
	Measurement Range: 1.33 – 1.53 RI; 0 – 95% Brix, 1.000 – 1.0500 Urine SG Accuracy:0.0002 Urine SG; 0.00004 RI; 0.01 Brix Electronic Temperature Control:Fixed temperature selection: 20°C and 25°C	The J-Series Refractometer is chosen by more toxicology labs than any other brand. These customers know that 0.0002 Urine SG accuracy must be validated regularly and Rudolph’s J57 refractometer ensures that the refractive index performance and calibration requirements meet government regulations. The J57HA’s standard sample volume is 500 micro liters but this can be reduced to 100 micro liters by selecting theJ57HA-SV.
	Measurement Range: 1.33 – 1.53 RI; 0 – 95% Brix, 1.000 – 1.0500 Urine SG Accuracy:0.0002 Urine SG; 0.00004 RI; 0.01 Brix Electronic Temperature Control:Fixed temperature selection: 20°C and 25°C	SAMSHA labs doing hundreds of toxicology samples per day prefer to eliminate the human factor and choose large scale automation. The J57HA-UF-SP refractometer is combined with a custom automation solution that minimizes sample use and replaces the tested sample to the testing vial.
	Measurement Range: 1.33 – 1.53 RI; 0 – 95% Brix, 1.000 – 1.0500 Urine SG Accuracy:0.0002 Urine SG; 0.00004 RI; 0.01 Brix Electronic Temperature Control:Fixed temperature selection: 20°C and 25°C	For large hospitals doing their own pharmaceutical compounding, ensuring that their Total Parenteral Nutrition formulas are accurate is life critical. The J57TPN is a Hospital Specific refractometer and was specifically customized to meet USP<797>. Please contact the factory for the white paper on this application.
	Measurement Range: 1.26 – 1.72 RI; 0 – 100% Brix Accuracy: 0.00002 RI; 0.015 Brix Electronic Temperature Control: Flexible temperature selection between 10°C to 100°C with ±0.01°C reproducibility.	Rudolph’s most capable refractometer. Perfect for today’s highly regulated laboratories offering full 21CFR Part 11 compliance. Rudolph Research is the first manufacturer to offer  Smart Measure™a system that notifies the operator of the quality and status of the sample load, as well as the sample well status. This assists the operator in producing more accurate readings, and actually documenting that the sample was properly loaded. The J457 is available in 3 configurations J457 SC – Standard Bench-top, J457 WC – Wall Mount, and the J457 FC – Factory Configuration. These configurations allow the measurement unit to be isolated from the display unit, thus protecting it from harsh environments and messy spills.